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October 19, 2015

Physiological processes in the body are in large part determined by the composition of secreted proteins found in the circulatory systems, including the blood. Each of the hundreds of proteins in the blood has a specific life span that determines its unique range of abundance. In fact, measurements of their quantities and activities contribute to many clinical diagnoses. However, the way in which normal protein concentrations in the blood are determined and maintained has been a mystery for decades.

August 20, 2015

Bacteria are pretty wily creatures. Take for example, an organism such as Salmonella, which succumbs to antibiotics in lab tests, but can become highly resistant in the body.
It is an example of what UC Santa Barbara biologist Michael Mahan refers to as the Trojan horse strategy. Identified through new research conducted by Mahan and his colleagues, the Trojan horse strategy may explain why antibiotics are ineffective in some patients despite lab tests that predict otherwise. The research findings appear in the journal EBioMedicine.

August 01, 2015

We are pleased to announce a new member of the CNM and our second inter-institutional adjunct professorial position.  Dr. Jeffrey W. Smith, a world expert in protein proteolysis in health and disease has joined the CNM effective August 1, 2015.  “We are delighted to have Jeff among our faculty, he is an exceptional biomedical researcher and a key collaborator in many of the ongoing CNM research projects at UCSB.”  Said Dr. Jamey Marth, director of the CNM.  Dr. Smith is a senior faculty member of the Sanford-Burnham Prebys (SBP) Medical Discovery Institute.  “I am pleased to join the CNM, it is an exceptional team of biomedical scientists working at the forefront of understanding and treating diseases that affect millions of humans.  Our collaborative work in sepsis research for example, is leading to new discoveries that are transforming our understanding of this deadly syndrome.  I am also excited to contribute to CNM projects on diabetes, inflammatory bowel diseases, and autoimmune diseases.  In addition, the magnificent research of Dr. Erkki Ruoslahti, co-founder of the CNM, is leading the way to new and more effective nanoparticle-based treatments of cancer.  The CNM represents a unique and successful combination of technologically inclined and biomedically relevant research, and is an unparalleled research institute at UCSB.” 

June 24, 2015

Our partner institute the Sanford-Burnham Medical Research Institute has received a gift of $100 million from prominent San Diego developer, philanthropist, and Sanford-Burnham honorary trustee Conrad Prebys.  This is the largest donation ever made by Prebys and will be used to further implement the Institute’s 10-year strategic vision to accelerate the delivery of innovative new treatments that will have a tangible impact on improving human health.  “A gift of this magnitude is significant in many ways,” said Sanford-Burnham Chief Executive Officer Perry Nisen, M.D., Ph.D.  “It enables us to conduct translational research to advance laboratory discoveries and clinic-ready drug candidates further along the development pipeline, progressing toward therapies, preventions, and cures for patients who desperately need them.  We are profoundly grateful to Conrad Prebys for this extraordinary gift.” 

In recognition of Prebys’ contribution, Sanford-Burnham Medical Research Institute will now bear his name, along with the other Institute namesakes T. Denny Sanford and Malin Burnham.  Effective June 24, the new name is now the Sanford Burnham Prebys Medical Discovery Institute.

January 13, 2015

For the third consecutive year, the Wille Family Foundation has provided a generous donation to the Center for Nanomedicine. “We are very appreciative that the Wille Family Foundation has chosen the Center for Nanomedicine as a recipient of its philanthropic efforts. In the era of fewer federal research dollars available, funding of biomedical research has been increasingly supported by philanthropic organizations.” said Dr. Jamey Marth, Co-Founder of the CNM. “This gift will promote the unique research and development programs at CNM focused on achieving more effective treatments and cures for diseases and syndromes such as sepsis, autoimmunity, cancer, and diabetes.”

October 28, 2014

UCSB biomedical scientist receives $3.5M NIH grant to expand his research on sepsis.

June 09, 2014

Scientists at the Center for Nanomedicine, in collaboration with researchers at the Sanford-Burnham Medical Research Institute and UCSB, have designed a nanoparticle that has unique — and important — properties. Spherical in shape and silver in composition, it is encased in a shell coated with a peptide that enables it to target tumor cells. What’s more, the shell is etchable so those nanoparticles that don’t hit their target can be broken down and eliminated. These research findings are published in the journal Nature Materials.

January 28, 2014

The Wille Family Foundation has provided another generous donation to the UCSB Center for Nanomedicine (CNM). Their donation will greatly facilitate the ability to move forward to support scientists and their research on grievous disease mechanisms and the development of nanomedicine-based treatments, as well as enable further fundraising efforts. Dr. Marth and all of the members of the CNM extend their deep appreciation and gratitude to the Richard Wille and the Wille Family Foundation for this generous and timely donation.

January 14, 2014

The Center for Nanomedicine has received a generous donation from the Djernaes Telos Foundation of Santa Barbara. This gift recognizes Christina A. Djernaes who passed away December 20, 2012 after a battle with cancer. CNM Co-Founders Erkki Ruoslahti and Jamey Marth met with Christina after her diagnosis and spoke at length on new technologies and treatments involving nanomediciine that may ultimately provide a cure. It is with sadness and disappointment that Drs. Marth and Ruoslahti learned of Christina’s passing in 2012. “The battle to conquer cancer will continue, it is inevitable that we will win.” said Dr. Marth. “The courage, spirit and generosity of people such as Christina guide us and motivate us to work harder and to never give up. Today, as we remember Christina, we extend out best wishes to her family and friends, and express our thanks to the Djernaes Telos Foundation for their support of us in our search for a cure.”

November 26, 2013

Sepsis, the body’s response to severe infections, kills more people than breast cancer, prostate cancer and HIV/AIDS combined. On average, 30 percent of those diagnosed with sepsis die.

January 30, 2013

Erkki Ruoslahti, M.D., Ph.D., co-founder of the CNM, and his laboratory have published a groundbreaking study in which they have designed a novel peptide capable of penetrating tumors for therapeutic treatment. A major problem in the treatment of cancer is getting anti-cancer drugs both to the site of the tumor and in contact with all cancer cells of the tumor. Their results recently published show that a tumor-specific tissue-penetrating peptide can be constructed de novo from known sequence elements. This principle may be useful in designing tissue-penetrating peptides for cancer and other diseases.

January 04, 2013

While legions of medical researchers have been looking to understand the genetic basis of disease and how mutations may affect human health, a group of biomedical researchers at UC Santa Barbara is studying the metabolism of cells and their surrounding tissue, to ferret out ways in which certain diseases begin. This approach, which includes computer modeling, can be applied to Type 2 diabetes, autoimmune diseases, and neurodegenerative diseases, among others.

September 19, 2012

Thomson Reuters’ annual predictions of who’ll win a Nobel Prize this year includes two cancer researchers, Tony Hunter at the Salk Institute and Erkki Ruoslahti of the Sanford-Burnham Medical Research Institute.

March 27, 2012

KEY News and Dr. Marth discuss how the passage of Proposition 29 would revive cancer research in California, and lead to breakthroughs in treatment and cures. Read more about this on

March 27, 2012

Dr. Ruoslahti is scheduled to give a lecture discussing his research on the use of targeted nanoparticles in cancer diagnosis and treatment.

March 27, 2012

Dr. Marth believes the passage of Prop 29 would be a game changer for medical researchers pursuing treatments and cures for cancer. Visit the Pacific Coast Business Times to read their informational article: “New cigarette tax could be breath of fresh air for cancer researchers.”

February 02, 2012

The Hearst Foundations have awarded Sanford-Burnham Medical Research Institute (Sanford-Burnham) with a grant to advance research in the Institute’s Center for Nanomedicine (CNM), led by Director Jamey Marth, Ph.D.

October 05, 2011

Sanford Burnham Prebys and Salk Institute scientists combine tumor-targeting peptides and nanoparticles to eliminate glioblastoma in a previously untreatable mouse model.