Cancer

Cancer is one of the most deadly of diseases.   In cancer, cells become immortal and grow in an unrestricted manner.  This results in tumors and cancer cell spread throughout the body by a process called metastasis.  There is typically no rehabilitation of cancer cells, the most effective approaches are the elimination of cancer cells by various means that cause cell death.  While many cancers become resistant to cell death pathways, new technologies are being developed that provide more effective means of targeting and eliminating cancer cells and tumors.  Nanomedicine is one such new technology that CNM scientists are using to increase the effectiveness of cancer drugs, and to enhance the elimination of tumor cells.  CNM scientists have devised multiple nanoparticle approaches that enable cancer drugs, for example, to home to tumors and subsequently to enter into tumors with increased infiltrating capabilities thereby exposing more of the tumor to drugs that can eliminate cancer cells.  The ability to target drugs and imaging agents to diseases such as cancer is one of the next major steps required to ultimately focus new drugs and treatments to diseased tissues while sparing normal healthy tissues and thereby reducing side effects.